Major(s): Molecular and Cell Biology
College: Eighth College
UC San Diego graduation year: 2029
Which research programs/experiences have you been a part of?
What is your research about?
I am currently researching how specific variants within the TGF-B Latent Complex proteins in patient-derived Stem Cells lead to aberrant, increased TGF-B expression and bioavailability within the placenta. By utilizing patient-derived stem cells, we model the disease "in a dish" using the patient’s exact genetic code. These stem cells were derived from patients with Preeclampsia and patients without Preeclampsia in order for us to compare the impact the Preeclampsia has on our generative model of the placenta. The Fisch lab aims to assess how these specific variants disrupt the TGF-B signaling.
Why and how did you decide to get involved in undergraduate research?
Through the PATHS program at UC San Diego, I was matched with Dr. Kathleen Fisch as my mentor, which gave me a pathway to transition into her lab. I wanted to see how the Molecular and Cell Biology concepts I learn in class apply directly to women’s health. Working under Dr. Fisch and Dr. Cindy Barba has allowed me to turn my curiosity into hands-on, high-impact research.
What has been the most exciting/interesting thing you've discovered through your research?
The coolest part of my work in Dr. Fisch's lab is using patient-derived stem cells to model preeclampsia "in a dish" using a patient's exact DNA. It's mind-blowing to watch how tiny genetic variants in TGFb Latent Complex proteins lead to abnormal protein levels in the placenta. Seeing these exact genetic variants disrupt cell signaling in real-time makes the project feel truly impactful!
What did you gain from this program/experience?
Thanks to the PATHS program, the URS summer experience, and the Doris A. Howell Foundation scholarship, I have grown tremendously as an undergraduate scientist and gained hands-on skills in stem cell culture. I learned how to tackle complex biological questions while seeing firsthand how our work directly supports women's health. Above all, having great mentorship in the Fisch lab built my confidence to trust my instincts at the bench and under the U.V hood.
What advice would you give to students starting research?
Taking full advantage of research programs like URH and having supportive mentors like Dr. Fisch and Dr. Barba makes all the difference! Do not be afraid to ask questions even if you feel like you are still learning the basics.
What are your future plans?
My goal is to become a Physician-Scientist because I am interested in translating biomedical research to clinical outcomes.
Anything else you want to share?
Additionally, I sincerely thank the Doris A. Howell Foundation, URS staff, and Dr. Kathleen Fisch for this wonderful opportunity. None of this would be possible without the guidance from the Fisch Lab members, especially my mentor Dr. Barba, thank you!